Academics land £2m prizes at Zuckerberg-backed ‘science Oscars’ – Ian Sample Sunday 8 November 2015 21.00 EST

British researcher John Hardy among those to win a Breakthrough prize at ceremony hosted by Seth MacFarlane in the US

Facebook’s Mark Zuckerberg, left, and Russian billionaire Yuri Milner

Science is starting to pay big for a small minority who land major prizes. At a ceremony in California on Sunday night, six researchers became substantially wealthier when they were handed Breakthrough prizes, set up by the Russian billionaire Yuri Milner along with some of the biggest names in Silicon Valley.

Among those honoured were Karl Deisseroth of Stanford University and Edward Boyden of MIT for developing a procedure called optogenetics – a means of turning neurons on and off using light. They took home $3m (£2m) apiece for winning the Breakthrough prize in life sciences.

The same prize winnings went to John Hardy, who studies Alzheimer’s disease at University College London; Helen Hobbs, of the University of Texas South-western medical centre, for discovering gene variants linked to cholesterol; Svante Pääbo at the Max Planck Institute for Evolutionary Anthropology in Leipzig for reading Neanderthal and other ancient genomes; and Ian Agol, a mathematician at the Institute for Advanced Study in Princeton, for his work on problems that language cannot easily convey: virtual Hakenvirtual fibering conjectures and tameness.

A group of 1,300 researchers won the Breakthrough prize in fundamental physics, but the $3m will be shared among five team leaders whose experiments confirmed that ghostly subatomic particles called neutrinos have mass. The same landmark discovery won the Nobel prize in physics this year.

In keeping with Milner’s aim of raising scientists to rock star status in the eyes of the public, the Breakthrough prizes – sometimes called the Oscars of science – were handed out at a ceremony at Hangar One in Silicon Valley hosted by Seth MacFarlane, the creator of Family Guy.

Pharrell Williams was down to perform, with Russell Crowe, Hilary Swank and Lily Collins among the guest presenters. The plan for the evening, with a theme of “life in the universe”, included a live video link to the Nasa astronaut Scott Kelly on the International Space Station.

The prizes, totalling $21.9m this year – taking the total handed out to more than $160m since they were established in 2012 – are backed by Facebook’s Mark Zuckerberg and his partner, Priscilla Chan, Google’s Sergey Brin, Anne Wojcicki of 23andme, and Jack Ma of and his wife, Cathy Zhang. Unlike Nobel prizes, the Breakthrough prizes are explicitly directed at researchers who are still active in their fields.

Hardy, nicknamed Scruffy by his former colleagues – he was once crowned the worst dressed scientist in the field at a major neuroscience conference – won the prize for his discovery of genetic mutations that give rise to early-onset Alzheimer’s disease, and for inspiring new treatments for preventing the disease.

He said he was having bacon and eggs in his kitchen one Saturday morning when Mahlon DeLong, a US neurologist from the prize committee, called with the news of his win. “I was speechless. It was a 15-minute call that changed my life. I had to have another cup of coffee,” he said.

Hardy is the most cited Alzheimer’s researcher in Britain, and may be the most storied too. He once rang up a $1,000 bill at an Osaka karaoke bar, drinking whiskey and singing Yellow Submarine, while in the city for a conference. One tale has him travelling with a colleague and mistakenly picking up the wrong suitcase before retiring to bed. The next day, Hardy appeared in the other man’s clothes. “He said he just thought his wife had bought him some new clothes,” a former colleague, Karen Duff, told the journal Nature Medicine in 2004.

He made a major breakthrough in 1990 at Imperial College London when his team found mutations that helped to explain how amyloid plaques form in the brain. Later, he showed that tangles of a protein called tau appeared to happen as the disease progressed. It was part of a strategy to understand the order in which Alzheimer’s takes hold.

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Watch: Jon Hamm won an Emmy — after 16 tries – Updated by Todd VanDerWerff on September 20, 2015, 11:20 p.m. ET

Screen Shot 2015-09-21 at Sep 21, 2015 12.27

Jon Hamm has been nominated for an Emmy 16 times. Eight of those nominations were for Don Draper, the iconic character he created on Mad Men. (Four others were for producing Mad Men, with another four for guest actor roles on Tina Fey shows.)

And until Sunday, September 20, he had never won a single one of those Emmys. But on his last chance, Hamm took home the Outstanding Lead Actor in a Drama Series award for playing Don. Fey presented him with the award, and the crowd gave him a standing ovation.

It wasn’t just his first Emmy. It was the first Emmy ever for an actor from Mad Men. The series’ total now stands at one win out of 36 separate nominations. (Elisabeth Moss and Christina Hendricks both lost their final bids for playing Peggy Olsen and Joan Holloway, respectively.)

It’s worth it, though, because Don’s one of the best characters in TV history, and Hamm had the unfortunate luck to be up against Bryan Cranston on Breaking Bad, who won four of the awards Hamm lost. (The other three went to Friday Night Lights‘ Kyle Chandler, Homeland‘s Damian Lewis, and The Newsroom‘s Jeff Daniels.)

Hamm, who’s had a tumultuous personal year, complete with time spent in rehab and a breakup of his longtime relationship, gave a short but touching speech that talked about the many people who’ve helped him on the journey to this moment, the families who’ve taken him into their lives and kept him going.

“To Bud and Susie and Mary Ann and Ted and Ernie and Carolyn and Vick and Linda and Gary and Sue and my sisters and Cora and Jen, thank you all very much. I would not be standing here without you,” he said. He then thanked the fans of the show and left, never to be Draper again.